InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDX2

Summary

InnateDB Gene

IDBG-19823.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDX2

Gene Name

caudal type homeobox 2

Synonyms

CDX-3; CDX2/AS; CDX3

Species

Homo sapiens

Ensembl Gene

ENSG00000165556

Encoded Proteins

IDBP-19825

caudal type homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:27962137-27971139

Strand

Reverse strand

Band

q12.2

Transcripts

ENST00000381020	ENSP00000370408
ENST00000548877

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0001890	placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0008284	positive regulation of cell proliferation
GO:0008333	endosome to lysosome transport
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0030154	cell differentiation
GO:0035019	somatic stem cell maintenance
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060711	labyrinthine layer development

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029646

View Gene Order

ENSBTAG00000001819

Not yet available

Pathways

NETPATH

REACTOME

REACT_24019

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway

REACT_23974

Incretin synthesis, secretion, and inactivation pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.174249 Hs.740844

RefSeq

NM_001265

HUGO

OMIM

CCDS

CCDS9328

HPRD

02622

IMGT

EMBL

GenPept

RNA Seq Atlas