Version 5.4
Homo sapiens Gene: IFNAR2
Summary
InnateDB Gene IDBG-1973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNAR2
Gene Name interferon (alpha, beta and omega) receptor 2
Synonyms IFN-alpha-REC; IFN-R; IFNABR; IFNARB
Species Homo sapiens
Ensembl Gene ENSG00000159110
Encoded Proteins
IDBP-1975
interferon (alpha, beta and omega) receptor 2
IDBP-1983
interferon (alpha, beta and omega) receptor 2
IDBP-1985
interferon (alpha, beta and omega) receptor 2
IDBP-1987
interferon (alpha, beta and omega) receptor 2
IDBP-292621
interferon (alpha, beta and omega) receptor 2
IDBP-362701
interferon (alpha, beta and omega) receptor 2
IDBP-362703
interferon (alpha, beta and omega) receptor 2
IDBP-362705
interferon (alpha, beta and omega) receptor 2
IDBP-362709
interferon (alpha, beta and omega) receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12220192
The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. Binding of interferon (IFN)-alpha to IFNAR2;IL10RB results in STAT2 binding and the initiation of the IFN signaling cascade.
PMID 20483775
Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.
Entrez Gene
Summary The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33229901-33265675
Strand Forward strand
Band q22.11
Transcripts
ENST00000382264 ENSP00000371699
ENST00000342136 ENSP00000343957
ENST00000342101 ENSP00000343289
ENST00000382238 ENSP00000371673
ENST00000404220 ENSP00000384309
ENST00000420068
ENST00000443073 ENSP00000403569
ENST00000413881 ENSP00000413160
ENST00000447980 ENSP00000402311
ENST00000417007 ENSP00000398799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004905 type I interferon receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019962 type I interferon binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007166 cell surface receptor signaling pathway
GO:0007259 JAK-STAT cascade
GO:0008283 cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0035455 response to interferon-alpha
GO:0045087 innate immune response (InnateDB)
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022971
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IFN alpha signaling pathway
PID NCI
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512211 Hs.708195
RefSeq NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584 NM_207585
HUGO
OMIM
CCDS CCDS13621 CCDS13622 CCDS74782
HPRD 03850
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca