InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NNT

Summary

InnateDB Gene

IDBG-19690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NNT

Gene Name

nicotinamide nucleotide transhydrogenase

Synonyms

GCCD4

Species

Homo sapiens

Ensembl Gene

ENSG00000112992

Encoded Proteins

IDBP-19694

nicotinamide nucleotide transhydrogenase

IDBP-19696

nicotinamide nucleotide transhydrogenase

IDBP-476231

nicotinamide nucleotide transhydrogenase

IDBP-475817

nicotinamide nucleotide transhydrogenase

IDBP-479607

nicotinamide nucleotide transhydrogenase

IDBP-482212

nicotinamide nucleotide transhydrogenase

IDBP-485315

nicotinamide nucleotide transhydrogenase

IDBP-480093

nicotinamide nucleotide transhydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:43602692-43707405

Strand

Forward strand

Band

p12

Transcripts

ENST00000344920	ENSP00000343873
ENST00000264663	ENSP00000264663
ENST00000505678	ENSP00000427670
ENST00000512422	ENSP00000421886
ENST00000512996	ENSP00000426343
ENST00000515208	ENSP00000425542
ENST00000506893
ENST00000503651	ENSP00000421674
ENST00000513390
ENST00000503059	ENSP00000424782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003957	NAD(P)+ transhydrogenase (B-specific) activity
GO:0008746	NAD(P)+ transhydrogenase activity
GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity
GO:0016491	oxidoreductase activity
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0015992	proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005746	mitochondrial respiratory chain
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025453

View Gene Order

ENSBTAG00000011885

Not yet available

Pathways

NETPATH

REACTOME

REACT_1785

Citric acid cycle (TCA cycle) pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00760

Nicotinate and nicotinamide metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D6RCR6 D6RHU2

UniProt Splice Variant

Entrez Gene

23530

UniGene

Hs.482043 Hs.566360 Hs.676575

RefSeq

NM_012343 NM_182977 XM_005248274 XM_005248275 XM_006714461

HUGO

HGNC:7863

OMIM

607878

CCDS

CCDS3949

HPRD

09715

IMGT

EMBL

AC010435

GenPept

RNA Seq Atlas

23530