InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSD

Summary

InnateDB Gene

IDBG-19613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSD

Gene Name

cathepsin D

Synonyms

CLN10; CPSD; HEL-S-130P

Species

Homo sapiens

Ensembl Gene

ENSG00000117984

Encoded Proteins

IDBP-19617

cathepsin D

IDBP-106024

cathepsin D

IDBP-361214

cathepsin D

IDBP-361216

cathepsin D

IDBP-361219

cathepsin D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18762176

Cathepsins: key modulators of cell death and inflammatory responses

Entrez Gene

Summary

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:1752752-1763992

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000236671	ENSP00000236671
ENST00000367196	ENSP00000356164
ENST00000433655	ENSP00000404902
ENST00000429746	ENSP00000402586
ENST00000438213	ENSP00000415036
ENST00000497544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	31 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0008219	cell death
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0031012	extracellular matrix
GO:0042470	melanosome
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome