InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HMGCS1

Summary

InnateDB Gene

IDBG-19361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCS1

Gene Name

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Synonyms

HMGCS

Species

Homo sapiens

Ensembl Gene

ENSG00000112972

Encoded Proteins

IDBP-19363

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

IDBP-366423

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

IDBP-474023

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:43289395-43313512

Strand

Reverse strand

Band

p12

Transcripts

ENST00000325110	ENSP00000322706
ENST00000433297	ENSP00000399402
ENST00000508319
ENST00000514610
ENST00000507004
ENST00000507293
ENST00000511774	ENSP00000427339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004421	hydroxymethylglutaryl-CoA synthase activity
GO:0008144	drug binding
GO:0016853	isomerase activity
GO:0042803	protein homodimerization activity
GO:0043177	organic acid binding

Biological Process

GO:0001889	liver development
GO:0006629	lipid metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0007420	brain development
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0008584	male gonad development
GO:0009645	response to low light intensity stimulus
GO:0009725	response to hormone
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0033197	response to vitamin E
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046690	response to tellurium ion
GO:0055094	response to lipoprotein particle stimulus
GO:0070723	response to cholesterol
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071397	cellular response to cholesterol
GO:0071407	cellular response to organic cyclic compound