InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BDKRB2

Summary

InnateDB Gene

IDBG-18990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BDKRB2

Gene Name

bradykinin receptor B2

Synonyms

B2R; BK-2; BK2; BKR2; BRB2

Species

Homo sapiens

Ensembl Gene

ENSG00000168398

Encoded Proteins

IDBP-599709

bradykinin receptor B2

IDBP-595700

bradykinin receptor B2

IDBP-584073

bradykinin receptor B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18810490

Involved in the early immune response against Listeria infection by increasing the production of IL12A/IL12B in human monocyte-derived dentritic cells

Entrez Gene

Summary

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:96204679-96244166

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000542454	ENSP00000439459
ENST00000554311	ENSP00000450482
ENST00000539359	ENSP00000438376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004947	bradykinin receptor activity
GO:0005515	protein binding
GO:0031702	type 1 angiotensin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006939	smooth muscle contraction
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008015	blood circulation
GO:0008152	metabolic process
GO:0009651	response to salt stress
GO:0019229	regulation of vasoconstriction
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0043114	regulation of vascular permeability
GO:0045087	innate immune response (InnateDB)
GO:0050482	arachidonic acid secretion
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902239	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator