InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SFRP1

Summary

InnateDB Gene

IDBG-18868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP1

Gene Name

secreted frizzled-related protein 1

Synonyms

FRP; FRP-1; FRP1; FrzA; SARP2

Species

Homo sapiens

Ensembl Gene

ENSG00000104332

Encoded Proteins

IDBP-18870

secreted frizzled-related protein 1

IDBP-18872

secreted frizzled-related protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:41261958-41309497

Strand

Reverse strand

Band

p11.21

Transcripts

ENST00000220772	ENSP00000220772
ENST00000379845	ENSP00000369174

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008201	heparin binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042802	identical protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0001944	vasculature development
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006508	proteolysis
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009267	cellular response to starvation
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0010564	regulation of cell cycle process
GO:0010629	negative regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0014034	neural crest cell fate commitment
GO:0014070	response to organic cyclic compound
GO:0021915	neural tube development
GO:0022601	menstrual cycle phase
GO:0030097	hemopoiesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030279	negative regulation of ossification
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0032855	positive regulation of Rac GTPase activity
GO:0033689	negative regulation of osteoblast proliferation
GO:0035019	somatic stem cell maintenance
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0044345	stromal-epithelial cell signaling involved in prostate gland development
GO:0045578	negative regulation of B cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045765	regulation of angiogenesis
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046546	development of primary male sexual characteristics
GO:0046676	negative regulation of insulin secretion
GO:0046851	negative regulation of bone remodeling
GO:0048147	negative regulation of fibroblast proliferation
GO:0048546	digestive tract morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060218	hematopoietic stem cell differentiation
GO:0060346	bone trabecula formation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071305	cellular response to vitamin D
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0071456	cellular response to hypoxia
GO:0071481	cellular response to X-ray
GO:0071504	cellular response to heparin
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071773	cellular response to BMP stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090246	convergent extension involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052	positive regulation of non-canonical Wnt signaling pathway
GO:2000054	negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000080	negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270	negative regulation of fibroblast apoptotic process
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome