InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLRX5

Summary

InnateDB Gene

IDBG-18709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRX5

Gene Name

glutaredoxin 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182512

Encoded Proteins

IDBP-18711

glutaredoxin 5

IDBP-584588

glutaredoxin 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:95533503-95544724

Strand

Forward strand

Band

q32.13

Transcripts

ENST00000331334	ENSP00000328570
ENST00000553672
ENST00000557731	ENSP00000451800

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021102

View Gene Order

ENSBTAG00000013423

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.728210

RefSeq

NM_016417

HUGO

OMIM

CCDS

CCDS9936

HPRD

12659

IMGT

EMBL

GenPept

RNA Seq Atlas