Version 5.4
Homo sapiens Gene: RABGEF1
Summary
InnateDB Gene IDBG-18687.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RABGEF1
Gene Name RAB guanine nucleotide exchange factor (GEF) 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154710
Encoded Proteins
IDBP-18695
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-376909
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-376914
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-376915
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-376917
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-810158
RAB guanine nucleotide exchange factor (GEF) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66682164-66811464
Strand Forward strand
Band q11.21
Transcripts
ENST00000284957 ENSP00000284957
ENST00000450873 ENSP00000415815
ENST00000442563 ENSP00000415503
ENST00000439720 ENSP00000403429
ENST00000437078 ENSP00000390480
ENST00000484547
ENST00000461017
ENST00000607882 ENSP00000476796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0002686 negative regulation of leukocyte migration
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0032851 positive regulation of Rab GTPase activity
GO:0033004 negative regulation of mast cell activation
GO:0043305 negative regulation of mast cell degranulation
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050728 negative regulation of inflammatory response
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 negative regulation of interleukin-6 secretion
GO:1900235 negative regulation of Kit signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0031982 vesicle
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025340
View Gene Order
ENSBTAG00000003842
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL C9JDA2 V9GYI8
UniProt Splice Variant
Entrez Gene 27342
UniGene
RefSeq NM_001287060 NM_001287061 NM_001287062 NM_014504
HUGO HGNC:17676
OMIM 609700
CCDS CCDS5535 CCDS69308 CCDS75610
HPRD
IMGT
EMBL AC027644 AC079588
GenPept
RNA Seq Atlas 27342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca