Version 5.4
Homo sapiens Gene: DICER1
Summary
InnateDB Gene IDBG-18522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DICER1
Gene Name dicer 1, ribonuclease type III
Synonyms DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2
Species Homo sapiens
Ensembl Gene ENSG00000100697
Encoded Proteins
IDBP-18524
dicer 1, ribonuclease type III
IDBP-244361
dicer 1, ribonuclease type III
IDBP-589944
dicer 1, ribonuclease type III
IDBP-591598
dicer 1, ribonuclease type III
IDBP-586091
dicer 1, ribonuclease type III
IDBP-593318
dicer 1, ribonuclease type III
IDBP-583147
dicer 1, ribonuclease type III
IDBP-603977
dicer 1, ribonuclease type III
IDBP-586408
dicer 1, ribonuclease type III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22252463
Down-regulation of DICER1 elicits an interferon response in endometrial cancer cells.
InnateDB Annotation from Orthologs
Summary
PMID 22252463
[Mus musculus] Down-regulation of Dicer1 elicits an interferon response in endometrial cancer cells.
Entrez Gene
Summary This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:95086228-95158010
Strand Reverse strand
Band q32.13
Transcripts
ENST00000343455 ENSP00000343745
ENST00000393063 ENSP00000376783
ENST00000526495 ENSP00000437256
ENST00000527416
ENST00000527414 ENSP00000435681
ENST00000556045 ENSP00000451041
ENST00000527554
ENST00000532939 ENSP00000452556
ENST00000554367
ENST00000556681
ENST00000532458
ENST00000529206
ENST00000531162 ENSP00000433060
ENST00000529720 ENSP00000433926
ENST00000541352 ENSP00000444719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
GO:0035198 miRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001942 hair follicle development
GO:0006396 RNA processing
GO:0008283 cell proliferation
GO:0009791 post-embryonic development
GO:0010070 zygote asymmetric cell division
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010626 negative regulation of Schwann cell proliferation
GO:0010628 positive regulation of gene expression
GO:0014040 positive regulation of Schwann cell differentiation
GO:0019827 stem cell maintenance
GO:0021522 spinal cord motor neuron differentiation
GO:0021675 nerve development
GO:0021889 olfactory bulb interneuron differentiation
GO:0021987 cerebral cortex development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031054 pre-miRNA processing
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0032290 peripheral nervous system myelin formation
GO:0035116 embryonic hindlimb morphogenesis
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035264 multicellular organism growth
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0045069 regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045595 regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0048255 mRNA stabilization
GO:0048536 spleen development
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0048856 anatomical structure development
GO:0050767 regulation of neurogenesis
GO:0051225 spindle assembly
GO:0051252 regulation of RNA metabolic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0055013 cardiac muscle cell development
GO:0060119 inner ear receptor cell development
GO:0060576 intestinal epithelial cell development
GO:0070173 regulation of enamel mineralization
GO:0071335 hair follicle cell proliferation
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628 regulation of miRNA metabolic process
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041415
View Gene Order
ENSBTAG00000012852
Not yet available
Pathways
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL Q5D0K5
UniProt Splice Variant
Entrez Gene 23405
UniGene Hs.595502 Hs.612400 Hs.613716 Hs.738957 Hs.87889
RefSeq NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438
HUGO HGNC:17098
OMIM 606241
CCDS CCDS55941 CCDS9931
HPRD 05875
IMGT
EMBL AL356017 AL390254 AY929254 AY929255
GenPept AAX18334 AAX18335
RNA Seq Atlas 23405

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca