Version 5.4
Homo sapiens Gene: CD151
Summary
InnateDB Gene IDBG-18403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD151
Gene Name CD151 molecule (Raph blood group)
Synonyms GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
Species Homo sapiens
Ensembl Gene ENSG00000177697
Encoded Proteins
IDBP-18405
CD151 molecule (Raph blood group)
IDBP-235407
CD151 molecule (Raph blood group)
IDBP-235409
CD151 molecule (Raph blood group)
IDBP-598812
CD151 molecule (Raph blood group)
IDBP-595920
CD151 molecule (Raph blood group)
IDBP-600242
CD151 molecule (Raph blood group)
IDBP-592968
CD151 molecule (Raph blood group)
IDBP-583889
CD151 molecule (Raph blood group)
IDBP-586265
CD151 molecule (Raph blood group)
IDBP-586014
CD151 molecule (Raph blood group)
IDBP-583149
CD151 molecule (Raph blood group)
IDBP-596362
CD151 molecule (Raph blood group)
IDBP-602459
CD151 molecule (Raph blood group)
IDBP-588882
CD151 molecule (Raph blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:832843-839831
Strand Forward strand
Band p15.5
Transcripts
ENST00000322008 ENSP00000324101
ENST00000397421 ENSP00000380566
ENST00000397420 ENSP00000380565
ENST00000525718 ENSP00000435854
ENST00000530155
ENST00000529810 ENSP00000432258
ENST00000526693 ENSP00000435054
ENST00000525333 ENSP00000431671
ENST00000525868
ENST00000531999
ENST00000524748 ENSP00000431403
ENST00000527341 ENSP00000436591
ENST00000526661
ENST00000530726 ENSP00000432385
ENST00000532045
ENST00000528867 ENSP00000433752
ENST00000530320 ENSP00000433787
ENST00000526439 ENSP00000434663
ENST00000528011 ENSP00000432990
ENST00000532075
ENST00000525181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0031581 hemidesmosome assembly
GO:0034329 cell junction assembly
GO:0042098 T cell proliferation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025510
View Gene Order
ENSBTAG00000019569
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_20676
Cell junction organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PK37 E9PP93
UniProt Splice Variant
Entrez Gene 977
UniGene Hs.654379
RefSeq NM_001039490 NM_004357 NM_139029 NM_139030
HUGO HGNC:1630
OMIM 602243
CCDS CCDS7719
HPRD 03763
IMGT
EMBL AP006621 AP006623
GenPept
RNA Seq Atlas 977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca