Version 5.4
Homo sapiens Gene: SMAD3
Summary
InnateDB Gene IDBG-18366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMAD3
Gene Name SMAD family member 3
Synonyms HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3
Species Homo sapiens
Ensembl Gene ENSG00000166949
Encoded Proteins
IDBP-18368
SMAD family member 3
IDBP-376027
SMAD family member 3
IDBP-590238
SMAD family member 3
IDBP-598077
SMAD family member 3
IDBP-747043
IDBP-602405
SMAD family member 3
IDBP-744536
IDBP-598450
SMAD family member 3
IDBP-583751
SMAD family member 3
IDBP-595854
SMAD family member 3
IDBP-596564
SMAD family member 3
IDBP-747589
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25410655
TGF-β signalling upregulates MIR181A2 expression through SMAD3/4-dependent promoter activation.
Entrez Gene
Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:67063763-67195195
Strand Forward strand
Band q22.33
Transcripts
ENST00000327367 ENSP00000332973
ENST00000439724 ENSP00000401133
ENST00000559460 ENSP00000453082
ENST00000559937
ENST00000559092 ENSP00000453788
ENST00000560175 ENSP00000455095
ENST00000540846 ENSP00000437757
ENST00000558894 ENSP00000458060
ENST00000558739 ENSP00000453684
ENST00000537194 ENSP00000445348
ENST00000558428 ENSP00000454165
ENST00000558827 ENSP00000452767
ENST00000560402
ENST00000560424 ENSP00000455540
ENST00000558763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 529 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 529 [view]
Protein-Protein 508 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0000988 protein binding transcription factor activity
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0035326 enhancer binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001933 negative regulation of protein phosphorylation
GO:0001947 heart looping
GO:0002076 osteoblast development
GO:0002520 immune system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006810 transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0008285 negative regulation of cell proliferation
GO:0009880 embryonic pattern specification
GO:0010467 gene expression
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 evasion or tolerance of host defenses by virus
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0031053 primary miRNA processing
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0032924 activin receptor signaling pathway
GO:0033689 negative regulation of osteoblast proliferation
GO:0035413 positive regulation of catenin import into nucleus
GO:0035556 intracellular signal transduction
GO:0038092 nodal signaling pathway
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045216 cell-cell junction organization
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0050821 protein stabilization
GO:0050927 positive regulation of positive chemotaxis
GO:0051098 regulation of binding
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060039 pericardium development
GO:0060290 transdifferentiation
GO:0061045 negative regulation of wound healing
GO:0070306 lens fiber cell differentiation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0043235 receptor complex
GO:0071141 SMAD protein complex
GO:0071144 SMAD2-SMAD3 protein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032402
View Gene Order
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_150238
Signaling by Activin pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_111057
Signaling by NODAL pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04520
Adherens junction pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
tgfbrpathway
TGF-beta receptor signaling
smad2_3pathway
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P84022
TrEMBL A0A024R5Z3 H0YKE2 H0YL71 H0YMP2 H0YNV1 H3BP09 Q68DS8
UniProt Splice Variant
Entrez Gene 4088
UniGene Hs.36915 Hs.727986 Hs.742270
RefSeq NM_005902 XM_006720506 NM_001145102 NM_001145103 NM_001145104
HUGO HGNC:6769
OMIM 603109
CCDS CCDS10222 CCDS45288 CCDS53950 CCDS53951
HPRD 08533
IMGT
EMBL AB004930 AC012568 AC087482 AF025293 AF025294 AF025295 AF025296 AF025297 AF025298 AF025299 AF025300 AK290881 AK298139 AK300614 AK316017 BC050743 CH471082 CR749287 U68019 U76622
GenPept AAB18967 AAB80960 AAH50743 AAL68976 BAA22032 BAF83570 BAH12731 BAH13315 BAH14388 CAH18142 EAW77788 EAW77789 EAW77790
RNA Seq Atlas 4088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca