Version 5.4
Homo sapiens Gene: CAMKK1
Summary
InnateDB Gene IDBG-17992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAMKK1
Gene Name calcium/calmodulin-dependent protein kinase kinase 1, alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000004660
Encoded Proteins
IDBP-17996
calcium/calmodulin-dependent protein kinase kinase 1, alpha
IDBP-17998
calcium/calmodulin-dependent protein kinase kinase 1, alpha
IDBP-18002
calcium/calmodulin-dependent protein kinase kinase 1, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:3860315-3894891
Strand Reverse strand
Band p13.2
Transcripts
ENST00000381769 ENSP00000371188
ENST00000348335 ENSP00000323118
ENST00000158166 ENSP00000158166
ENST00000573483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007268 synaptic transmission
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020785
View Gene Order
ENSBTAG00000007166
Not yet available
Pathways
NETPATH
REACTOME
REACT_20661
CREB phosphorylation through the activation of CaMKK pathway
REACT_13685
Neuronal System pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.621824 Hs.8417
RefSeq NM_032294 NM_172206 NM_172207 XM_005256820
HUGO
OMIM
CCDS CCDS11038 CCDS11039
HPRD 13000
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca