InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IRAK2

Summary

InnateDB Gene

IDBG-17914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRAK2

Gene Name

interleukin-1 receptor-associated kinase 2

Synonyms

IRAK-2

Species

Homo sapiens

Ensembl Gene

ENSG00000134070

Encoded Proteins

IDBP-17916

interleukin-1 receptor-associated kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17878161

IRAK2 has a role in TRAF6 ubiquitination in the Toll-like receptor (TLR) pathway and thus plays a more central role than IRAK1 in TLR signalling to NFkappaB.

PMID 18438411

IRAK2 is critical in late-phase Toll-like receptor (TLR) responses, and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation.

PMID 19224918

IRAK2 is required for LPS-mediated post-transcriptional control of cytokine and chemokine expression, which plays an essential role in TLR4-induced septic shock.

PMID 21291324

IRAK2 induces cytokine and chemokine mRNA stability and translation in response to LPS stimulation in macrophages. The kinase activity of IRAK2 is required for the optimal activation of mitogen activated protein kinase signaling, which regulates cytokine/chemokine production at posttranscriptional levels.

PMID 21606490

IRAK2 is required for both TLR4 and TLR8-mediated activation of NFkB and p38 MAP kinase, and the induction of TNF mRNA. In addition, IRAK2 is required for regulating MYD88-dependent TNF-alpha mRNA stability. (Phenotype was not observed in murine ortholog, Irak2)

InnateDB Annotation from Orthologs

Summary

PMID 21291324

[Mus musculus] Irak2 regulates cytokine and chemokine mRNA stability and translation in response to LPS stimulation in macrophages. The kinase activity of Irak2 is required for the optimal activation of mitogen activated protein kinase signalling, which regulates cytokine/chemokine production at post-transcriptional levels.

Entrez Gene

Summary

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:10164865-10243743

Strand

Forward strand

Band

p25.3

Transcripts

ENST00000256458

ENSP00000256458

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	78 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001959	regulation of cytokine-mediated signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1