Homo sapiens Gene: WASF3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-17879.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | WASF3 | ||||||||||||||||||||||
Gene Name | WAS protein family, member 3 | ||||||||||||||||||||||
Synonyms | Brush-1; SCAR3; WAVE3 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000132970 | ||||||||||||||||||||||
Encoded Proteins |
WAS protein family, member 3
WAS protein family, member 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq, Jul 2008] This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 13:26557703-26688948 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q12.13 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Signaling by VEGF pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
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KEGG |
Adherens junction pathway
Fc gamma R-mediated phagocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9UPY6 | ||||||||||||||||||||||
TrEMBL | B4DGR1 Q5T8P4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10810 | ||||||||||||||||||||||
UniGene | Hs.618732 Hs.731015 Hs.737259 | ||||||||||||||||||||||
RefSeq | NM_001291965 NM_006646 XM_005266239 | ||||||||||||||||||||||
HUGO | HGNC:12734 | ||||||||||||||||||||||
OMIM | 605068 | ||||||||||||||||||||||
CCDS | CCDS9318 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB020707 AB026543 AF134305 AF454702 AK289845 AK294725 AL159978 AL163538 AL353789 BC050283 CH471075 | ||||||||||||||||||||||
GenPept | AAD33054 AAH50283 AAL51032 BAA74923 BAA81796 BAF82534 BAG57872 CAH72487 EAX08388 EAX08389 | ||||||||||||||||||||||
RNA Seq Atlas | 10810 | ||||||||||||||||||||||