InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYNJ1

Summary

InnateDB Gene

IDBG-1770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNJ1

Gene Name

synaptojanin 1

Synonyms

INPP5G; PARK20

Species

Homo sapiens

Ensembl Gene

ENSG00000159082

Encoded Proteins

IDBP-1774

synaptojanin 1

IDBP-1780

synaptojanin 1

IDBP-1782

synaptojanin 1

IDBP-362327

synaptojanin 1

IDBP-362340

synaptojanin 1

IDBP-362343

synaptojanin 1

IDBP-362348

synaptojanin 1

IDBP-362352

synaptojanin 1

IDBP-362354

synaptojanin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:32628759-32728048

Strand

Reverse strand

Band

q22.11

Transcripts

ENST00000357345	ENSP00000349903
ENST00000382499	ENSP00000371939
ENST00000382491	ENSP00000371931
ENST00000438952	ENSP00000388869
ENST00000433931	ENSP00000409667
ENST00000418301	ENSP00000387868
ENST00000416083	ENSP00000413480
ENST00000429236	ENSP00000413649
ENST00000456084	ENSP00000412707
ENST00000467445
ENST00000464778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006836	neurotransmitter transport
GO:0007612	learning
GO:0008219	cell death
GO:0016082	synaptic vesicle priming
GO:0016191	synaptic vesicle uncoating
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048488	synaptic vesicle endocytosis
GO:0048489	synaptic vesicle transport