Homo sapiens Gene: M6PR | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-17511.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | M6PR | ||||||||||||||||||
Gene Name | mannose-6-phosphate receptor (cation dependent) | ||||||||||||||||||
Synonyms | CD-MPR; MPR 46; MPR-46; MPR46; SMPR | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000003056 | ||||||||||||||||||
Encoded Proteins |
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 12:8940363-8949955 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p13.31 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Lysosome Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
trans-Golgi Network Vesicle Budding pathway
Membrane Trafficking pathway
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KEGG |
Lysosome pathway
Phagosome pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.134084 Hs.685756 | ||||||||||||||||||
RefSeq | NM_001207024 NM_002355 XM_005253376 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS73440 CCDS8598 | ||||||||||||||||||
HPRD | 01106 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||