InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BAG4

Summary

InnateDB Gene

IDBG-17465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG4

Gene Name

BCL2-associated athanogene 4

Synonyms

BAG-4; SODD

Species

Homo sapiens

Ensembl Gene

ENSG00000156735

Encoded Proteins

IDBP-17467

BCL2-associated athanogene 4

IDBP-366982

BCL2-associated athanogene 4

IDBP-481190

BCL2-associated athanogene 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:38176533-38213301

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000287322	ENSP00000287322
ENST00000432471	ENSP00000393298
ENST00000521282
ENST00000521311	ENSP00000430250

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0010763	positive regulation of fibroblast migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072659	protein localization to plasma membrane
GO:0090367	negative regulation of mRNA modification
GO:0097178	ruffle assembly
GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037316

View Gene Order

ENSBTAG00000013143

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

tnfpathway

TNF receptor signaling pathway

hivnefpathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

Cross-References

SwissProt

TrEMBL

H0YBT1

UniProt Splice Variant

Entrez Gene

9530

UniGene

Hs.194726 Hs.545396 Hs.606090 Hs.628792

RefSeq

NM_001204878 NM_004874

HUGO

HGNC:940

OMIM

603884

CCDS

CCDS56533 CCDS6104

HPRD

04861

IMGT

EMBL

AC084024

GenPept

RNA Seq Atlas

9530