InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TEC

Summary

InnateDB Gene

IDBG-17328.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEC

Gene Name

tec protein tyrosine kinase

Synonyms

PSCTK4

Species

Homo sapiens

Ensembl Gene

ENSG00000135605

Encoded Proteins

IDBP-17330

tec protein tyrosine kinase

IDBP-482612

tec protein tyrosine kinase

IDBP-478643

tec protein tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:48135783-48269864

Strand

Reverse strand

Band

p11

Transcripts

ENST00000381501	ENSP00000370912
ENST00000505452	ENSP00000424567
ENST00000515146	ENSP00000424365
ENST00000511150
ENST00000511471

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0010543	regulation of platelet activation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042246	tissue regeneration
GO:0045087	innate immune response
GO:0050853	B cell receptor signaling pathway