InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPV1

Summary

InnateDB Gene

IDBG-17215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV1

Gene Name

transient receptor potential cation channel, subfamily V, member 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000196689

Encoded Proteins

IDBP-17219

transient receptor potential cation channel, subfamily V, member 1

IDBP-229782

transient receptor potential cation channel, subfamily V, member 1

IDBP-229784

transient receptor potential cation channel, subfamily V, member 1

IDBP-361720

transient receptor potential cation channel, subfamily V, member 1

IDBP-759885

IDBP-760495

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:3565444-3597098

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000310522	ENSP00000311692
ENST00000399759	ENSP00000382661
ENST00000399756	ENSP00000382659
ENST00000425167	ENSP00000409627
ENST00000571088	ENSP00000461007
ENST00000574085
ENST00000570742
ENST00000576351	ENSP00000459042

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005216	ion channel activity
GO:0005231	excitatory extracellular ligand-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0015278	calcium-release channel activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007166	cell surface receptor signaling pathway
GO:0007635	chemosensory behavior
GO:0034220	ion transmembrane transport
GO:0050955	thermoception
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031226	intrinsic component of plasma membrane
GO:0032591	dendritic spine membrane
GO:0045211	postsynaptic membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

pi3kplctrkpathway

Trk receptor signaling mediated by PI3K and PLC-gamma

mapktrkpathway

Trk receptor signaling mediated by the MAPK pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.655380

RefSeq

NM_018727 NM_080705 NM_080706

HUGO

OMIM

CCDS

CCDS45576

HPRD

03648

IMGT

EMBL

GenPept

RNA Seq Atlas