Version 5.4
Homo sapiens Gene: BRF2
Summary
InnateDB Gene IDBG-17067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRF2
Gene Name BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104221
Encoded Proteins
IDBP-17069
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
IDBP-477697
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
IDBP-474427
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
IDBP-479140
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:37843268-37849904
Strand Reverse strand
Band p11.23
Transcripts
ENST00000220659 ENSP00000220659
ENST00000520601 ENSP00000430107
ENST00000521170 ENSP00000430193
ENST00000522539 ENSP00000429554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031487
View Gene Order
ENSBTAG00000027665
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.709301
RefSeq NM_018310
HUGO
OMIM
CCDS CCDS6098
HPRD 06115
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca