Version 5.4
Homo sapiens Gene: CABYR
Summary
InnateDB Gene IDBG-1684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CABYR
Gene Name calcium binding tyrosine-(Y)-phosphorylation regulated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154040
Encoded Proteins
IDBP-1690
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-230508
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-230510
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-230514
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-365671
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-599122
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-598040
calcium binding tyrosine-(Y)-phosphorylation regulated
IDBP-728099
IDBP-725669
IDBP-727302
IDBP-727148
IDBP-727289
IDBP-725676
IDBP-727674
IDBP-727139
IDBP-807294
calcium binding tyrosine-(Y)-phosphorylation regulated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:24138956-24161603
Strand Forward strand
Band q11.2
Transcripts
ENST00000327201 ENSP00000317095
ENST00000399499 ENSP00000382421
ENST00000399496 ENSP00000382419
ENST00000399481 ENSP00000382404
ENST00000415309 ENSP00000399973
ENST00000463087 ENSP00000432870
ENST00000486759 ENSP00000431142
ENST00000579102 ENSP00000462748
ENST00000581872 ENSP00000462474
ENST00000582229 ENSP00000462947
ENST00000585037 ENSP00000463737
ENST00000584752 ENSP00000462009
ENST00000577705 ENSP00000463781
ENST00000581397 ENSP00000462811
ENST00000579956 ENSP00000464595
ENST00000621648 ENSP00000483621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003351 epithelial cilium movement
GO:0048240 sperm capacitation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
GO:0097228 sperm principal piece
GO:0097229 sperm end piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024430
View Gene Order
ENSBTAG00000005638
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511983
RefSeq NM_012189 NM_138643 NM_138644 NM_153768 NM_153769 NM_153770 XM_005258246
HUGO
OMIM
CCDS CCDS11881 CCDS11882 CCDS11883 CCDS42420 CCDS45840
HPRD 10806
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca