Version 5.4
Homo sapiens Gene: NANOG
Summary
InnateDB Gene IDBG-16534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NANOG
Gene Name Nanog homeobox
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111704
Encoded Proteins
IDBP-16536
Nanog homeobox
IDBP-594056
Nanog homeobox
IDBP-599423
Nanog homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:7787794-7799141
Strand Forward strand
Band p13.31
Transcripts
ENST00000229307 ENSP00000229307
ENST00000541267 ENSP00000444434
ENST00000526434
ENST00000526286 ENSP00000435288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 156 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001710 mesodermal cell fate commitment
GO:0001714 endodermal cell fate specification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008406 gonad development
GO:0009790 embryo development
GO:0009880 embryonic pattern specification
GO:0010033 response to organic substance
GO:0010454 negative regulation of cell fate commitment
GO:0010468 regulation of gene expression
GO:0017145 stem cell division
GO:0019827 stem cell maintenance
GO:0030154 cell differentiation
GO:0030514 negative regulation of BMP signaling pathway
GO:0032526 response to retinoic acid
GO:0035019 somatic stem cell maintenance
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048863 stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012396
View Gene Order
ENSBTAG00000020916
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_200670
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5GZI2
UniProt Splice Variant
Entrez Gene 79923
UniGene Hs.598820 Hs.635882
RefSeq NM_001297698 NM_024865 XM_005253484
HUGO HGNC:20857
OMIM 607937
CCDS CCDS31736 CCDS73436
HPRD 06397
IMGT
EMBL AC006517
GenPept
RNA Seq Atlas 79923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca