InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RANBP1

Summary

InnateDB Gene

IDBG-1621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANBP1

Gene Name

RAN binding protein 1

Synonyms

HTF9A

Species

Homo sapiens

Ensembl Gene

ENSG00000099901

Encoded Proteins

IDBP-1623

RAN binding protein 1

IDBP-292560

RAN binding protein 1

IDBP-362779

RAN binding protein 1

IDBP-362783

RAN binding protein 1

IDBP-362788

RAN binding protein 1

IDBP-362799

RAN binding protein 1

IDBP-362802

RAN binding protein 1

IDBP-362806

RAN binding protein 1

IDBP-362808

RAN binding protein 1

IDBP-362812

RAN binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [provided by RefSeq, Jul 2008]
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:20115938-20127357

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000331821	ENSP00000327583
ENST00000402752	ENSP00000384925
ENST00000435265	ENSP00000390139
ENST00000432879	ENSP00000404724
ENST00000430524	ENSP00000401564
ENST00000411892	ENSP00000395472
ENST00000416427	ENSP00000404126
ENST00000421656	ENSP00000400940
ENST00000423859	ENSP00000404298
ENST00000418705	ENSP00000413502
ENST00000448394
ENST00000488484
ENST00000467920
ENST00000486575

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0008536	Ran GTPase binding

Biological Process

GO:0007051	spindle organization
GO:0007165	signal transduction
GO:0016032	viral process
GO:0043547	positive regulation of GTPase activity
GO:0046604	positive regulation of mitotic centrosome separation
GO:0046907	intracellular transport
GO:0050790	regulation of catalytic activity