InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DAPK2

Summary

InnateDB Gene

IDBG-16095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPK2

Gene Name

death-associated protein kinase 2

Synonyms

DRP-1; DRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000035664

Encoded Proteins

IDBP-16097

death-associated protein kinase 2

IDBP-374900

death-associated protein kinase 2

IDBP-586053

death-associated protein kinase 2

IDBP-595706

death-associated protein kinase 2

IDBP-591390

death-associated protein kinase 2

IDBP-591155

death-associated protein kinase 2

IDBP-602672

death-associated protein kinase 2

IDBP-809519

death-associated protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:63907036-64072033

Strand

Reverse strand

Band

q22.31

Transcripts

ENST00000261891	ENSP00000261891
ENST00000457488	ENSP00000408277
ENST00000559007	ENSP00000453639
ENST00000559731
ENST00000558064	ENSP00000453101
ENST00000557867
ENST00000558069	ENSP00000453235
ENST00000558076
ENST00000558482
ENST00000559897
ENST00000561162	ENSP00000453284
ENST00000559306	ENSP00000452970
ENST00000612884	ENSP00000484390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0010506	regulation of autophagy
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043276	anoikis
GO:0046777	protein autophosphorylation
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0034423	autophagic vacuole lumen

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000032380

View Gene Order

Pathways

NETPATH

REACTOME

REACT_22128

Role of DCC in regulating apoptosis pathway

REACT_578

Apoptosis pathway

REACT_13648

Regulation of Apoptosis pathway

KEGG

hsa05219

Bladder cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.237886 Hs.603282 Hs.623561

RefSeq

NM_014326 XM_005254265 XM_005254266 XM_005254268

HUGO

OMIM

CCDS

CCDS10188

HPRD

09905

IMGT

EMBL

GenPept

RNA Seq Atlas