InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS6KA5

Summary

InnateDB Gene

IDBG-16084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA5

Gene Name

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Synonyms

MSK1; MSPK1; RLPK

Species

Homo sapiens

Ensembl Gene

ENSG00000100784

Encoded Proteins

IDBP-16086

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-375857

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-591942

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-583862

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-603151

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-601034

ribosomal protein S6 kinase, 90kDa, polypeptide 5

IDBP-809021

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18690222

RPS6KA5 negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL10 and DUSP1 promoters.

PMID 19922413

RPS6KA5 regulates the transcription of IL1RA in response to TLR activation in macrophages.

PMID 25520509

Paramyxoviruses trigger the DNA-damage response, a pathway required for RPS6KA5 activation of phospho Ser 276 RELA formation to trigger the IRF7-DDX58 amplification loop necessary for mucosal interferon production.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:90847862-91060636

Strand

Reverse strand

Band

q32.11

Transcripts

ENST00000261991	ENSP00000261991
ENST00000418736	ENSP00000402787
ENST00000536315	ENSP00000442803
ENST00000556178	ENSP00000451305
ENST00000554206	ENSP00000450591
ENST00000556304
ENST00000556594	ENSP00000451736
ENST00000614987	ENSP00000479667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.

Experimentally validated
Total	80 [view]
Protein-Protein	72 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007411	axon guidance
GO:0009103	lipopolysaccharide biosynthetic process
GO:0016572	histone phosphorylation
GO:0032793	positive regulation of CREB transcription factor activity
GO:0033129	positive regulation of histone phosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035066	positive regulation of histone acetylation
GO:0035556	intracellular signal transduction
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043987	histone H3-S10 phosphorylation
GO:0043988	histone H3-S28 phosphorylation
GO:0043990	histone H2A-S1 phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070498	interleukin-1-mediated signaling pathway