Version 5.4
Homo sapiens Gene: UBXN8
Summary
InnateDB Gene IDBG-15914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBXN8
Gene Name UBX domain protein 8
Synonyms D8S2298E; REP8; UBXD6
Species Homo sapiens
Ensembl Gene ENSG00000104691
Encoded Proteins
IDBP-812240
UBX domain protein 8
IDBP-812248
UBX domain protein 8
IDBP-812243
UBX domain protein 8
IDBP-812237
UBX domain protein 8
IDBP-812252
UBX domain protein 8
IDBP-812236
UBX domain protein 8
IDBP-812251
UBX domain protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:30732247-30767006
Strand Forward strand
Band p12
Transcripts
ENST00000265616 ENSP00000479216
ENST00000341403 ENSP00000478502
ENST00000380154 ENSP00000482772
ENST00000522968 ENSP00000483433
ENST00000518059 ENSP00000480065
ENST00000620074 ENSP00000477532
ENST00000616306
ENST00000615729 ENSP00000481635
ENST00000620706
ENST00000613013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL B4DKK1
UniProt Splice Variant
Entrez Gene 7993
UniGene
RefSeq NM_001282189 NM_001282199 NM_005671
HUGO HGNC:30307
OMIM 602155
CCDS CCDS75723 CCDS75724 CCDS75725
HPRD
IMGT
EMBL AK296600
GenPept BAG59213
RNA Seq Atlas 7993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca