Version 5.4
Homo sapiens Gene: IGFBP3
Summary
InnateDB Gene IDBG-15809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP3
Gene Name insulin-like growth factor binding protein 3
Synonyms BP-53; IBP3
Species Homo sapiens
Ensembl Gene ENSG00000146674
Encoded Proteins
IDBP-15811
insulin-like growth factor binding protein 3
IDBP-15813
insulin-like growth factor binding protein 3
IDBP-15815
insulin-like growth factor binding protein 3
IDBP-374674
insulin-like growth factor binding protein 3
IDBP-374675
insulin-like growth factor binding protein 3
IDBP-374678
insulin-like growth factor binding protein 3
IDBP-808451
insulin-like growth factor binding protein 3
IDBP-808453
insulin-like growth factor binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45912245-45921874
Strand Reverse strand
Band p12.3
Transcripts
ENST00000275521 ENSP00000275521
ENST00000381086 ENSP00000370476
ENST00000381083 ENSP00000370473
ENST00000428530 ENSP00000390298
ENST00000417621 ENSP00000399116
ENST00000448817 ENSP00000389668
ENST00000460209
ENST00000465642
ENST00000460477
ENST00000615754 ENSP00000480717
ENST00000613132 ENSP00000477772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 27 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0008160 protein tyrosine phosphatase activator activity
GO:0031994 insulin-like growth factor I binding
GO:0046872 metal ion binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001933 negative regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0009968 negative regulation of signal transduction
GO:0010906 regulation of glucose metabolic process
GO:0014912 negative regulation of smooth muscle cell migration
GO:0040008 regulation of growth
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 cellular protein metabolic process
GO:0044342 type B pancreatic cell proliferation
GO:0045663 positive regulation of myoblast differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0016942 insulin-like growth factor binding protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020427
View Gene Order
ENSBTAG00000003994
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04115
p53 signaling pathway pathway
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
p53downstreampathway
Direct p53 effectors
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.450230 Hs.697535 Hs.737554
RefSeq NM_000598 NM_001013398
HUGO
OMIM
CCDS CCDS34632 CCDS5505
HPRD 00899
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca