Version 5.4
Homo sapiens Gene: RPA1
Summary
InnateDB Gene IDBG-15783.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPA1
Gene Name replication protein A1, 70kDa
Synonyms HSSB; MST075; REPA1; RF-A; RP-A; RPA70
Species Homo sapiens
Ensembl Gene ENSG00000132383
Encoded Proteins
IDBP-15787
replication protein A1, 70kDa
IDBP-761369
IDBP-762617
IDBP-763559
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1829702-1900082
Strand Forward strand
Band p13.3
Transcripts
ENST00000254719 ENSP00000254719
ENST00000574049 ENSP00000461466
ENST00000570451 ENSP00000459788
ENST00000571725
ENST00000573994
ENST00000571058 ENSP00000461733
ENST00000573924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 495 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 495 [view]
Protein-Protein 494 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0001701 in utero embryonic development
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0030097 hemopoiesis
GO:0032201 telomere maintenance via semi-conservative replication
GO:0048873 homeostasis of number of cells within a tissue
GO:0051276 chromosome organization
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000751
View Gene Order
ENSBTAG00000009711
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_7999
Removal of the Flap Intermediate from the C-strand pathway
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_2055
Processing of DNA double-strand break ends pathway
REACT_2141
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_408
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_1763
Homologous DNA pairing and strand exchange pathway
REACT_27271
Meiotic recombination pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_200819
Cellular response to heat stress pathway
REACT_1725
M/G1 Transition pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_111183
Meiosis pathway
REACT_200744
HSF1 activation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03440
Homologous recombination pathway
hsa03430
Mismatch repair pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.461925 Hs.595562
RefSeq NM_002945
HUGO
OMIM
CCDS CCDS11014
HPRD 01565
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca