Version 5.4
Homo sapiens Gene: PARP4
Summary
InnateDB Gene IDBG-15770.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP4
Gene Name poly (ADP-ribose) polymerase family, member 4
Synonyms ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P; VAULT3; VPARP; VWA5C
Species Homo sapiens
Ensembl Gene ENSG00000102699
Encoded Proteins
IDBP-15772
poly (ADP-ribose) polymerase family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:24420926-24512810
Strand Reverse strand
Band q12.12
Transcripts
ENST00000381989 ENSP00000371419
ENST00000484989
ENST00000480576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0006281 DNA repair
GO:0006464 cellular protein modification process
GO:0006471 protein ADP-ribosylation
GO:0006810 transport
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0008219 cell death
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054509
View Gene Order
ENSBTAG00000025400
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.117825 Hs.720806 Hs.743641
RefSeq NM_006437
HUGO
OMIM
CCDS CCDS9307
HPRD 09598
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca