Version 5.4
Homo sapiens Gene: IGFBP1
Summary
InnateDB Gene IDBG-15764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP1
Gene Name insulin-like growth factor binding protein 1
Synonyms AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12
Species Homo sapiens
Ensembl Gene ENSG00000146678
Encoded Proteins
IDBP-15766
insulin-like growth factor binding protein 1
IDBP-374643
insulin-like growth factor binding protein 1
IDBP-477448
insulin-like growth factor binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45888357-45893668
Strand Forward strand
Band p12.3
Transcripts
ENST00000275525 ENSP00000275525
ENST00000457280 ENSP00000413511
ENST00000468955 ENSP00000417069
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 2 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0030307 positive regulation of cell growth
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0042246 tissue regeneration
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020429
View Gene Order
ENSBTAG00000046768
Not yet available
Pathways
NETPATH
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.642938 Hs.705742
RefSeq NM_000596
HUGO
OMIM
CCDS CCDS5504
HPRD 00897
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca