InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTPN6

Summary

InnateDB Gene

IDBG-15719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN6

Gene Name

protein tyrosine phosphatase, non-receptor type 6

Synonyms

HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1

Species

Homo sapiens

Ensembl Gene

ENSG00000111679

Encoded Proteins

IDBP-15721

protein tyrosine phosphatase, non-receptor type 6

IDBP-230608

protein tyrosine phosphatase, non-receptor type 6

IDBP-365075

protein tyrosine phosphatase, non-receptor type 6

IDBP-584244

protein tyrosine phosphatase, non-receptor type 6

IDBP-591027

protein tyrosine phosphatase, non-receptor type 6

IDBP-602111

protein tyrosine phosphatase, non-receptor type 6

IDBP-808558

protein tyrosine phosphatase, non-receptor type 6

IDBP-603941

protein tyrosine phosphatase, non-receptor type 6

IDBP-586581

protein tyrosine phosphatase, non-receptor type 6

IDBP-603394

protein tyrosine phosphatase, non-receptor type 6

IDBP-600897

protein tyrosine phosphatase, non-receptor type 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 9520455

PTPN6 (SHP-1) normally functions to antagonize the IL-2 signal transduction pathway and human T-lymphotropic virus type I (HTLV-I) infection and oncogenic transformation can lead to loss of SHP-1 expression, resulting in constitutive activation of IL-2 regulated T cell responses.

PMID 8524272

PTPN6 reversibly associates with the IFN-alpha receptor complex upon IFN stimulation and selectively regulates distinct components of JAK/STAT signal transduction pathways.

PMID 17079228

PTPN6 specifically downregulates MAP3K7 (TAK1) through dephosphorylation, suppressing inflammatory responses via TAK1 signalling pathways.

PMID 18391954

PTPN6 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.

PMID 20145200

PTPN6 tyrosine phosphatase activity plays a critical role in induction of IL2B production in macrophages in response to TLR ligands.

InnateDB Annotation from Orthologs

Summary

PMID 25876760

[Mus musculus] Bordetella pertussis CyaA toxin plays a role in evading nitric oxide-mediated killing in macrophages through a cAMP-dependent activation of the Ptpn6 phosphatase.

Entrez Gene

Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6946468-6961316

Strand

Forward strand

Band

p13.31

Transcripts

ENST00000318974	ENSP00000326010
ENST00000399448	ENSP00000382376
ENST00000416215
ENST00000456013	ENSP00000391592
ENST00000543115	ENSP00000443393
ENST00000542848	ENSP00000444805
ENST00000543120
ENST00000534900
ENST00000538318
ENST00000538715	ENSP00000438740
ENST00000543744
ENST00000540740
ENST00000545153	ENSP00000476175
ENST00000536521
ENST00000535462	ENSP00000441044
ENST00000541698	ENSP00000445646
ENST00000542462	ENSP00000440114
ENST00000542277
ENST00000536013	ENSP00000446345
ENST00000539365
ENST00000539029
ENST00000542761
ENST00000537533

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	161 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470	protein dephosphorylation
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311	dephosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030154	cell differentiation
GO:0030220	platelet formation
GO:0031295	T cell costimulation
GO:0033277	abortive mitotic cell cycle
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035556	intracellular signal transduction
GO:0035855	megakaryocyte development
GO:0042130	negative regulation of T cell proliferation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045577	regulation of B cell differentiation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050853	B cell receptor signaling pathway
GO:0050859	negative regulation of B cell receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0042105	alpha-beta T cell receptor complex
GO:0070062	extracellular vesicular exosome