Version 5.4
Homo sapiens Gene: SIRT3
Summary
InnateDB Gene IDBG-15653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT3
Gene Name sirtuin 3
Synonyms SIR2L3
Species Homo sapiens
Ensembl Gene ENSG00000142082
Encoded Proteins
IDBP-15655
sirtuin 3
IDBP-594445
sirtuin 3
IDBP-597181
sirtuin 3
IDBP-591854
sirtuin 3
IDBP-603325
sirtuin 3
IDBP-585237
sirtuin 3
IDBP-602780
sirtuin 3
IDBP-589666
sirtuin 3
IDBP-594621
sirtuin 3
IDBP-589974
sirtuin 3
IDBP-589285
sirtuin 3
IDBP-594629
sirtuin 3
IDBP-603860
sirtuin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:215458-236931
Strand Reverse strand
Band p15.5
Transcripts
ENST00000382743 ENSP00000372191
ENST00000529937 ENSP00000434747
ENST00000532837 ENSP00000433899
ENST00000525319 ENSP00000435464
ENST00000524564 ENSP00000432937
ENST00000532956 ENSP00000433077
ENST00000529382 ENSP00000437216
ENST00000531753
ENST00000526854 ENSP00000435505
ENST00000529055 ENSP00000437179
ENST00000528702
ENST00000534381
ENST00000530067 ENSP00000435014
ENST00000528469 ENSP00000432857
ENST00000525776 ENSP00000433132
ENST00000525237 ENSP00000436085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 68 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0019899 enzyme binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006476 protein deacetylation
GO:0007568 aging
GO:0009060 aerobic respiration
GO:0034983 peptidyl-lysine deacetylation
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025486
View Gene Order
ENSBTAG00000002044
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL B7WNN4
UniProt Splice Variant
Entrez Gene 23410
UniGene Hs.716456 Hs.738004
RefSeq NM_001017524 NM_012239
HUGO HGNC:14931
OMIM 604481
CCDS CCDS53590 CCDS7691
HPRD 06836
IMGT
EMBL AC136475
GenPept
RNA Seq Atlas 23410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca