InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SERPINF1

Summary

InnateDB Gene

IDBG-15621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINF1

Gene Name

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Synonyms

EPC-1; OI12; OI6; PEDF

Species

Homo sapiens

Ensembl Gene

ENSG00000132386

Encoded Proteins

IDBP-15625

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

IDBP-759387

IDBP-759224

IDBP-764725

IDBP-761771

IDBP-761399

IDBP-763967

IDBP-759449

IDBP-758170

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:1761959-1777574

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000254722	ENSP00000254722
ENST00000577053	ENSP00000460842
ENST00000576406	ENSP00000461214
ENST00000572517
ENST00000571149	ENSP00000460905
ENST00000571870
ENST00000570731	ENSP00000459869
ENST00000572048	ENSP00000458484
ENST00000573770	ENSP00000459107
ENST00000571360	ENSP00000461660
ENST00000570820
ENST00000573763	ENSP00000461405

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0001822	kidney development
GO:0007275	multicellular organismal development
GO:0007568	aging
GO:0007614	short-term memory
GO:0008283	cell proliferation
GO:0010447	response to acidity
GO:0010596	negative regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0010951	negative regulation of endopeptidase activity
GO:0010976	positive regulation of neuron projection development
GO:0016525	negative regulation of angiogenesis
GO:0030162	regulation of proteolysis
GO:0042698	ovulation cycle
GO:0046685	response to arsenic-containing substance
GO:0050728	negative regulation of inflammatory response
GO:0050769	positive regulation of neurogenesis
GO:0060041	retina development in camera-type eye
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071279	cellular response to cobalt ion
GO:0071300	cellular response to retinoic acid
GO:0071333	cellular response to glucose stimulus
GO:0071549	cellular response to dexamethasone stimulus
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043203	axon hillock
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000753

View Gene Order

ENSBTAG00000009705

Not yet available

Cross-References

SwissProt

TrEMBL

I3L2R7 I3L3Z3 I3L425

UniProt Splice Variant

Entrez Gene

5176

UniGene

RefSeq

NM_002615

HUGO

HGNC:8824

OMIM

172860

CCDS

CCDS11012

HPRD

01408

IMGT

EMBL

AC130343 AC130689

GenPept

RNA Seq Atlas

102723646 5176