Version 5.4
Homo sapiens Gene: FOXN3
Summary
InnateDB Gene IDBG-15491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXN3
Gene Name forkhead box N3
Synonyms C14orf116; CHES1; PRO1635
Species Homo sapiens
Ensembl Gene ENSG00000053254
Encoded Proteins
IDBP-15493
forkhead box N3
IDBP-15495
forkhead box N3
IDBP-603464
forkhead box N3
IDBP-601306
forkhead box N3
IDBP-598319
forkhead box N3
IDBP-587951
forkhead box N3
IDBP-584900
forkhead box N3
IDBP-595918
forkhead box N3
IDBP-604004
forkhead box N3
IDBP-593776
forkhead box N3
IDBP-588063
forkhead box N3
IDBP-586202
forkhead box N3
IDBP-596481
forkhead box N3
IDBP-812131
forkhead box N3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:89124871-89619149
Strand Reverse strand
Band q32.11
Transcripts
ENST00000345097 ENSP00000343288
ENST00000261302 ENSP00000261302
ENST00000557572 ENSP00000450783
ENST00000557258 ENSP00000452005
ENST00000555353 ENSP00000452227
ENST00000553840 ENSP00000450833
ENST00000556541
ENST00000555010
ENST00000557496
ENST00000557718 ENSP00000451437
ENST00000553353 ENSP00000452444
ENST00000556916 ENSP00000450684
ENST00000555658
ENST00000554005 ENSP00000451024
ENST00000557261
ENST00000555855 ENSP00000451135
ENST00000555034 ENSP00000452290
ENST00000553904 ENSP00000451902
ENST00000615335 ENSP00000479114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000085 mitotic G2 phase
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033713
View Gene Order
ENSBTAG00000046684
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601559 Hs.621371
RefSeq NM_001085471 NM_005197
HUGO
OMIM
CCDS CCDS32138 CCDS41977
HPRD 07533
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca