InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TPM1

Summary

InnateDB Gene

IDBG-15400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPM1

Gene Name

tropomyosin 1 (alpha)

Synonyms

C15orf13; CMD1Y; CMH3; HTM-alpha; LVNC9; TMSA

Species

Homo sapiens

Ensembl Gene

ENSG00000140416

Encoded Proteins

IDBP-15402

tropomyosin 1 (alpha)

IDBP-15404

tropomyosin 1 (alpha)

IDBP-15406

tropomyosin 1 (alpha)

IDBP-15408

tropomyosin 1 (alpha)

IDBP-15410

tropomyosin 1 (alpha)

IDBP-15414

tropomyosin 1 (alpha)

IDBP-293824

tropomyosin 1 (alpha)

IDBP-293806

tropomyosin 1 (alpha)

IDBP-601251

tropomyosin 1 (alpha)

IDBP-586808

tropomyosin 1 (alpha)

IDBP-601644

tropomyosin 1 (alpha)

IDBP-592445

tropomyosin 1 (alpha)

IDBP-601601

tropomyosin 1 (alpha)

IDBP-587463

tropomyosin 1 (alpha)

IDBP-596543

tropomyosin 1 (alpha)

IDBP-587035

tropomyosin 1 (alpha)

IDBP-603583

tropomyosin 1 (alpha)

IDBP-599466

tropomyosin 1 (alpha)

IDBP-585720

tropomyosin 1 (alpha)

IDBP-590560

tropomyosin 1 (alpha)

IDBP-592099

tropomyosin 1 (alpha)

IDBP-593780

tropomyosin 1 (alpha)

IDBP-592741

tropomyosin 1 (alpha)

IDBP-593637

tropomyosin 1 (alpha)

IDBP-811033

tropomyosin 1 (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:63042632-63071915

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000358278	ENSP00000351022
ENST00000317516	ENSP00000322577
ENST00000288398	ENSP00000288398
ENST00000357980	ENSP00000350667
ENST00000267996	ENSP00000267996
ENST00000334895	ENSP00000334624
ENST00000404484	ENSP00000384315
ENST00000403994	ENSP00000385107
ENST00000560975
ENST00000560445	ENSP00000452999
ENST00000561425	ENSP00000453324
ENST00000558314
ENST00000558347	ENSP00000452887
ENST00000559556	ENSP00000453941
ENST00000559397	ENSP00000452879
ENST00000560970	ENSP00000453062
ENST00000561266	ENSP00000453955
ENST00000559831	ENSP00000452977
ENST00000558544	ENSP00000453817
ENST00000558868
ENST00000560959	ENSP00000453724
ENST00000559281	ENSP00000452658
ENST00000560615	ENSP00000453050
ENST00000560679	ENSP00000453136
ENST00000558264	ENSP00000452624
ENST00000558400
ENST00000561395	ENSP00000453092
ENST00000561242
ENST00000558072
ENST00000559108
ENST00000558910	ENSP00000452830
ENST00000560131
ENST00000610733	ENSP00000477929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0008092	cytoskeletal protein binding
GO:0008307	structural constituent of muscle

Biological Process

GO:0001701	in utero embryonic development
GO:0003065	positive regulation of heart rate by epinephrine
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0006937	regulation of muscle contraction
GO:0007010	cytoskeleton organization
GO:0008016	regulation of heart contraction
GO:0030049	muscle filament sliding
GO:0030336	negative regulation of cell migration
GO:0031529	ruffle organization
GO:0032781	positive regulation of ATPase activity
GO:0034614	cellular response to reactive oxygen species
GO:0042060	wound healing
GO:0045214	sarcomere organization
GO:0045785	positive regulation of cell adhesion
GO:0051496	positive regulation of stress fiber assembly
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005862	muscle thin filament tropomyosin
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0031941	filamentous actin
GO:0032059	bleb
GO:0032587	ruffle membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000032366

View Gene Order

Pathways

NETPATH

REACTOME

REACT_20558

Smooth Muscle Contraction pathway

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.635569 Hs.713685

RefSeq

NM_000366 NM_001018004 NM_001018005 NM_001018006 NM_001018007 NM_001018008 NM_001018020 NM_001301289 XM_005254637 XM_005254644 XM_005254646 XM_005254648 XM_005254650 XM_005254651 XM_005254652 XM_005254653 XM_006720668

HUGO

OMIM

CCDS

CCDS10181 CCDS32262 CCDS32263 CCDS32264 CCDS45273 CCDS58368 CCDS58369

HPRD

01839

IMGT

EMBL

GenPept

RNA Seq Atlas