InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PARN

Summary

InnateDB Gene

IDBG-15347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARN

Gene Name

poly(A)-specific ribonuclease

Synonyms

DAN

Species

Homo sapiens

Ensembl Gene

ENSG00000140694

Encoded Proteins

IDBP-15349

poly(A)-specific ribonuclease

IDBP-369088

poly(A)-specific ribonuclease

IDBP-369091

poly(A)-specific ribonuclease

IDBP-593583

poly(A)-specific ribonuclease

IDBP-598262

poly(A)-specific ribonuclease

IDBP-749954

IDBP-749680

IDBP-752964

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
The protein encoded by this gene is a 3\'-exoribonuclease, with similarity to the RNase D family of 3\'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:14435701-14632728

Strand

Reverse strand

Band

p13.12

Transcripts

ENST00000341484	ENSP00000345456
ENST00000437198	ENSP00000387911
ENST00000420015	ENSP00000410525
ENST00000539279	ENSP00000444381
ENST00000538472	ENSP00000445659
ENST00000569444	ENSP00000456279
ENST00000562715
ENST00000564113
ENST00000563641	ENSP00000458103
ENST00000564904
ENST00000564882
ENST00000566021
ENST00000563697
ENST00000562896	ENSP00000456982
ENST00000563155

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0004518	nuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402	mRNA catabolic process
GO:0007292	female gamete generation
GO:0009451	RNA modification
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic