InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRPF8

Summary

InnateDB Gene

IDBG-15306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF8

Gene Name

PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)

Synonyms

HPRP8; PRP8; PRPC8; RP13; SNRNP220

Species

Homo sapiens

Ensembl Gene

ENSG00000174231

Encoded Proteins

IDBP-15310

PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)

IDBP-762765

IDBP-759696

IDBP-763110

IDBP-764880

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:1650629-1684882

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000304992	ENSP00000304350
ENST00000574217
ENST00000573725	ENSP00000460849
ENST00000577001	ENSP00000458151
ENST00000573716
ENST00000575116
ENST00000573681
ENST00000572723
ENST00000572621	ENSP00000460348
ENST00000574728
ENST00000576585
ENST00000576407
ENST00000571346
ENST00000572445
ENST00000576958
ENST00000571958	ENSP00000459095

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	150 [view]
Protein-Protein	150 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017070	U6 snRNA binding
GO:0030623	U5 snRNA binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005682	U5 snRNP
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020850

View Gene Order

ENSBTAG00000011488

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.181368

RefSeq

NM_006445

HUGO

OMIM

CCDS

CCDS11010

HPRD

06295

IMGT

EMBL

GenPept

RNA Seq Atlas