InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPIA

Summary

InnateDB Gene

IDBG-15159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIA

Gene Name

peptidylprolyl isomerase A (cyclophilin A)

Synonyms

CYPA; CYPH; HEL-S-69p

Species

Homo sapiens

Ensembl Gene

ENSG00000196262

Encoded Proteins

IDBP-482860

peptidylprolyl isomerase A (cyclophilin A)

IDBP-374374

peptidylprolyl isomerase A (cyclophilin A)

IDBP-374383

peptidylprolyl isomerase A (cyclophilin A)

IDBP-477219

peptidylprolyl isomerase A (cyclophilin A)

IDBP-475292

peptidylprolyl isomerase A (cyclophilin A)

IDBP-480790

peptidylprolyl isomerase A (cyclophilin A)

IDBP-807161

peptidylprolyl isomerase A (cyclophilin A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20829794

PPIA (CYPA) is a cell-intrinsic sensor for human immunodeficiency virus 1 (HIV-1) that exists in dendritic cells and mediates an antiviral innate immune response.

Entrez Gene

Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44796680-44824564

Strand

Forward strand

Band

p13

Transcripts

ENST00000355968	ENSP00000430817
ENST00000451562	ENSP00000405975
ENST00000415933	ENSP00000394670
ENST00000468812	ENSP00000419425
ENST00000481437
ENST00000489459	ENSP00000427976
ENST00000479021	ENSP00000429251
ENST00000494484
ENST00000480603
ENST00000620047	ENSP00000479961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	79 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0042277	peptide binding
GO:0044822	poly(A) RNA binding
GO:0046790	virion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002576	platelet degranulation
GO:0006278	RNA-dependent DNA replication
GO:0006457	protein folding
GO:0007596	blood coagulation
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019061	uncoating of virus
GO:0019068	virion assembly
GO:0019076	viral release from host cell
GO:0030168	platelet activation
GO:0030260	entry into host cell
GO:0034389	lipid particle organization
GO:0045069	regulation of viral genome replication
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0050714	positive regulation of protein secretion
GO:0050900	leukocyte migration
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome