InnateDB: Systems Biology of the Innate Immune Response

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget\'s disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:11547722-11636381

Strand

Reverse strand

Band

p13.13

Transcripts

ENST00000381810	ENSP00000371231
ENST00000339430	ENSP00000340118
ENST00000413364	ENSP00000397958
ENST00000573332	ENSP00000460873
ENST00000575426	ENSP00000459094
ENST00000571277	ENSP00000459026
ENST00000571627	ENSP00000460743
ENST00000571976	ENSP00000460133
ENST00000570798	ENSP00000458871
ENST00000576334	ENSP00000458538
ENST00000571459	ENSP00000459603
ENST00000574703	ENSP00000459913
ENST00000574848	ENSP00000459898
ENST00000571688	ENSP00000459533
ENST00000574763	ENSP00000461813
ENST00000570904	ENSP00000459138
ENST00000572255	ENSP00000458836
ENST00000576036	ENSP00000461667
ENST00000574701	ENSP00000458981
ENST00000620789	ENSP00000481589
ENST00000622633	ENSP00000483114

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0050699	WW domain binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007568	aging
GO:0032496	response to lipopolysaccharide
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022500

View Gene Order

ENSBTAG00000005622

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.459940 Hs.561271

RefSeq

NM_001136472 NM_001136473 NM_004862 XM_006720982 XM_006720984 XM_006720985

HUGO

OMIM

CCDS

CCDS32386 CCDS45411

HPRD

10354

IMGT

EMBL

GenPept

RNA Seq Atlas