Version 5.4
Homo sapiens Gene: ING4
Summary
InnateDB Gene IDBG-14716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ING4
Gene Name inhibitor of growth family, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111653
Encoded Proteins
IDBP-14718
inhibitor of growth family, member 4
IDBP-236715
inhibitor of growth family, member 4
IDBP-364161
inhibitor of growth family, member 4
IDBP-364165
inhibitor of growth family, member 4
IDBP-364168
inhibitor of growth family, member 4
IDBP-364180
inhibitor of growth family, member 4
IDBP-587197
inhibitor of growth family, member 4
IDBP-592017
inhibitor of growth family, member 4
IDBP-589790
inhibitor of growth family, member 4
IDBP-813527
inhibitor of growth family, member 4
IDBP-584094
inhibitor of growth family, member 4
IDBP-587431
inhibitor of growth family, member 4
IDBP-813530
inhibitor of growth family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20534538
ING4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response. In mice, it facilitates NF-kappaB activation of IkappaB promoters, thereby suppressing nuclear RelA (p65) levels and the activation of select NF-kappaB target cytokines.
InnateDB Annotation from Orthologs
Summary
PMID 20534538
[Mus musculus] Ing4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response in mice by facilitating NF-kappaB activation of IkappaB promoters; thereby suppressing nuclear Rela (p65) levels and the activation of select NF-kappaB target cytokines.
Entrez Gene
Summary This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6650280-6663148
Strand Reverse strand
Band p13.31
Transcripts
ENST00000341550 ENSP00000343396
ENST00000396807 ENSP00000380024
ENST00000412586 ENSP00000412705
ENST00000437149
ENST00000444704 ENSP00000397343
ENST00000423703 ENSP00000414008
ENST00000446105 ENSP00000415903
ENST00000486287
ENST00000484795
ENST00000482489 ENSP00000435867
ENST00000469749 ENSP00000433081
ENST00000472002
ENST00000488381 ENSP00000431892
ENST00000467678 ENSP00000473635
ENST00000479301 ENSP00000436406
ENST00000493873 ENSP00000437198
ENST00000493267
ENST00000619641 ENSP00000480978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 44 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0006260 DNA replication
GO:0006325 chromatin organization
GO:0006473 protein acetylation
GO:0006915 apoptotic process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0016573 histone acetylation
GO:0043065 positive regulation of apoptotic process
GO:0043966 histone H3 acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030330
View Gene Order
ENSBTAG00000017064
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524210
RefSeq NM_001127582 NM_001127583 NM_001127584 NM_001127585 NM_001127586 NM_016162
HUGO
OMIM
CCDS CCDS44812 CCDS44813 CCDS44814 CCDS44815 CCDS44816 CCDS8555
HPRD 09774
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca