Version 5.4
Homo sapiens Gene: PBK
Summary
InnateDB Gene IDBG-14590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PBK
Gene Name PDZ binding kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168078
Encoded Proteins
IDBP-14594
PDZ binding kinase
IDBP-481650
PDZ binding kinase
IDBP-475479
PDZ binding kinase
IDBP-482086
PDZ binding kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27809620-27838095
Strand Reverse strand
Band p21.1
Transcripts
ENST00000301905 ENSP00000301905
ENST00000522944 ENSP00000428489
ENST00000524266 ENSP00000428438
ENST00000521226 ENSP00000427892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034644 cellular response to UV
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022033
View Gene Order
ENSBTAG00000021069
Not yet available
Cross-References
SwissProt
TrEMBL E5RIE1
UniProt Splice Variant
Entrez Gene 55872
UniGene Hs.104741 Hs.668270
RefSeq NM_001278945 NM_018492 XM_006716368
HUGO HGNC:18282
OMIM 611210
CCDS CCDS6063 CCDS64858
HPRD 17822
IMGT
EMBL AC104997
GenPept
RNA Seq Atlas 55872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca