Version 5.4
Homo sapiens Gene: APC2
Summary
InnateDB Gene IDBG-14549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APC2
Gene Name adenomatosis polyposis coli 2
Synonyms APCL
Species Homo sapiens
Ensembl Gene ENSG00000115266
Encoded Proteins
IDBP-14551
adenomatosis polyposis coli 2
IDBP-14553
adenomatosis polyposis coli 2
IDBP-592979
adenomatosis polyposis coli 2
IDBP-765913
IDBP-763654
IDBP-766082
IDBP-762019
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1446302-1473244
Strand Forward strand
Band p13.3
Transcripts
ENST00000233607 ENSP00000233607
ENST00000238483 ENSP00000238483
ENST00000535453 ENSP00000442954
ENST00000593146
ENST00000590877 ENSP00000466173
ENST00000587869 ENSP00000466803
ENST00000590469 ENSP00000467073
ENST00000587149 ENSP00000468199
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0035414 negative regulation of catenin import into nucleus
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005881 cytoplasmic microtubule
GO:0005884 actin filament
GO:0015630 microtubule cytoskeleton
GO:0016342 catenin complex
GO:0031258 lamellipodium membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020135
View Gene Order
ENSBTAG00000015433
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05213
Endometrial cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446376
RefSeq NM_005883 XM_005259475 XM_006722607 XM_006722608 XM_006722609 XM_006722610
HUGO
OMIM
CCDS CCDS12068
HPRD 09802
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca