InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK2B

Summary

InnateDB Gene

IDBG-14499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2B

Gene Name

calcium/calmodulin-dependent protein kinase II beta

Synonyms

CAM2; CAMK2; CAMKB

Species

Homo sapiens

Ensembl Gene

ENSG00000058404

Encoded Proteins

IDBP-14501

calcium/calmodulin-dependent protein kinase II beta

IDBP-14503

calcium/calmodulin-dependent protein kinase II beta

IDBP-14505

calcium/calmodulin-dependent protein kinase II beta

IDBP-14507

calcium/calmodulin-dependent protein kinase II beta

IDBP-14509

calcium/calmodulin-dependent protein kinase II beta

IDBP-14511

calcium/calmodulin-dependent protein kinase II beta

IDBP-14513

calcium/calmodulin-dependent protein kinase II beta

IDBP-238830

calcium/calmodulin-dependent protein kinase II beta

IDBP-238832

calcium/calmodulin-dependent protein kinase II beta

IDBP-374051

calcium/calmodulin-dependent protein kinase II beta

IDBP-374055

calcium/calmodulin-dependent protein kinase II beta

IDBP-374070

calcium/calmodulin-dependent protein kinase II beta

IDBP-374080

calcium/calmodulin-dependent protein kinase II beta

IDBP-374081

calcium/calmodulin-dependent protein kinase II beta

IDBP-374084

calcium/calmodulin-dependent protein kinase II beta

IDBP-374085

calcium/calmodulin-dependent protein kinase II beta

IDBP-477396

calcium/calmodulin-dependent protein kinase II beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44217150-44334577

Strand

Reverse strand

Band

p13

Transcripts

ENST00000258682	ENSP00000258682
ENST00000350811	ENSP00000326375
ENST00000353185	ENSP00000326600
ENST00000358707	ENSP00000351542
ENST00000347193	ENSP00000326544
ENST00000353625	ENSP00000326427
ENST00000346990	ENSP00000326518
ENST00000395749	ENSP00000379098
ENST00000395747	ENSP00000379096
ENST00000440254	ENSP00000397937
ENST00000457475	ENSP00000390292
ENST00000425809	ENSP00000410445
ENST00000433930	ENSP00000388951
ENST00000415369	ENSP00000390419
ENST00000424197	ENSP00000400387
ENST00000421607	ENSP00000388445
ENST00000427209
ENST00000523845	ENSP00000428912
ENST00000466584
ENST00000497584
ENST00000489429
ENST00000497127
ENST00000495819
ENST00000484972
ENST00000462128
ENST00000470984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0002030	inhibitory G-protein coupled receptor phosphorylation
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0010976	positive regulation of neuron projection development
GO:0014733	regulation of skeletal muscle adaptation
GO:0018105	peptidyl-serine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032222	regulation of synaptic transmission, cholinergic
GO:0046686	response to cadmium ion
GO:0046777	protein autophosphorylation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050885	neuromuscular process controlling balance
GO:0051823	regulation of synapse structural plasticity
GO:0051924	regulation of calcium ion transport
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060466	activation of meiosis involved in egg activation
GO:0060998	regulation of dendritic spine development
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0090129	positive regulation of synapse maturation
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030666	endocytic vesicle membrane
GO:0033017	sarcoplasmic reticulum membrane
GO:0051233	spindle midzone