InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCK

Summary

InnateDB Gene

IDBG-14358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCK

Gene Name

glucokinase (hexokinase 4)

Synonyms

FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2

Species

Homo sapiens

Ensembl Gene

ENSG00000106633

Encoded Proteins

IDBP-14360

glucokinase (hexokinase 4)

IDBP-14362

glucokinase (hexokinase 4)

IDBP-238814

glucokinase (hexokinase 4)

IDBP-294008

glucokinase (hexokinase 4)

IDBP-373753

glucokinase (hexokinase 4)

IDBP-808924

glucokinase (hexokinase 4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44144271-44198170

Strand

Reverse strand

Band

p13

Transcripts

ENST00000336642	ENSP00000338009
ENST00000345378	ENSP00000223366
ENST00000395796	ENSP00000379142
ENST00000403799	ENSP00000384247
ENST00000437084	ENSP00000402840
ENST00000459642
ENST00000473353
ENST00000476008
ENST00000616242	ENSP00000482149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0016301	kinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019903	protein phosphatase binding
GO:0043531	ADP binding

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006110	regulation of glycolytic process
GO:0006739	NADP metabolic process
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008645	hexose transport
GO:0009749	response to glucose
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016310	phosphorylation
GO:0019932	second-messenger-mediated signaling
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0032811	negative regulation of epinephrine secretion
GO:0032869	cellular response to insulin stimulus
GO:0042149	cellular response to glucose starvation
GO:0042327	positive regulation of phosphorylation
GO:0042593	glucose homeostasis
GO:0043266	regulation of potassium ion transport
GO:0044281	small molecule metabolic process
GO:0044320	cellular response to leptin stimulus
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0046835	carbohydrate phosphorylation
GO:0050796	regulation of insulin secretion
GO:0051156	glucose 6-phosphate metabolic process
GO:0051594	detection of glucose
GO:0055085	transmembrane transport
GO:0055088	lipid homeostasis
GO:0070509	calcium ion import

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0030141	secretory granule
GO:0045180	basal cortex