Version 5.4
Homo sapiens Gene: AEBP1
Summary
InnateDB Gene IDBG-14232.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AEBP1
Gene Name AE binding protein 1
Synonyms ACLP
Species Homo sapiens
Ensembl Gene ENSG00000106624
Encoded Proteins
IDBP-14234
AE binding protein 1
IDBP-373600
AE binding protein 1
IDBP-373601
AE binding protein 1
IDBP-373602
AE binding protein 1
IDBP-373607
AE binding protein 1
IDBP-373609
AE binding protein 1
IDBP-373611
AE binding protein 1
IDBP-373615
AE binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells. [provided by RefSeq, Jul 2008]
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44104361-44114562
Strand Forward strand
Band p13
Transcripts
ENST00000223357 ENSP00000223357
ENST00000455443 ENSP00000411277
ENST00000449162 ENSP00000401758
ENST00000453052 ENSP00000400660
ENST00000454218
ENST00000434445 ENSP00000397241
ENST00000450684 ENSP00000398878
ENST00000413907 ENSP00000410349
ENST00000431035 ENSP00000416568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0005516 calmodulin binding
GO:0008270 zinc ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007517 muscle organ development
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020473
View Gene Order
ENSBTAG00000012237
Not yet available
Cross-References
SwissProt
TrEMBL H7C0W8
UniProt Splice Variant
Entrez Gene 165
UniGene Hs.439463
RefSeq NM_001129
HUGO HGNC:303
OMIM 602981
CCDS CCDS5476
HPRD 04281
IMGT
EMBL AC006454
GenPept
RNA Seq Atlas 165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca