InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIN2A

Summary

InnateDB Gene

IDBG-14127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN2A

Gene Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Synonyms

EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A

Species

Homo sapiens

Ensembl Gene

ENSG00000183454

Encoded Proteins

IDBP-14129

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

IDBP-237210

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

IDBP-237212

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

IDBP-594339

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

IDBP-750790

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:9753409-10182754

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000330684	ENSP00000332549
ENST00000396575	ENSP00000379820
ENST00000396573	ENSP00000379818
ENST00000461292
ENST00000463531
ENST00000535259	ENSP00000441572
ENST00000566665
ENST00000566683
ENST00000562109	ENSP00000454998
ENST00000566670
ENST00000568247

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001964	startle response
GO:0001975	response to amphetamine
GO:0006810	transport
GO:0006816	calcium ion transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007611	learning or memory
GO:0007612	learning
GO:0007613	memory
GO:0008104	protein localization
GO:0008542	visual learning
GO:0009611	response to wounding
GO:0019233	sensory perception of pain
GO:0022008	neurogenesis
GO:0030431	sleep
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0040011	locomotion
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0042417	dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045471	response to ethanol
GO:0048167	regulation of synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0051930	regulation of sensory perception of pain
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density