InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHX2

Summary

InnateDB Gene

IDBG-14092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHX2

Gene Name

epoxide hydrolase 2, cytoplasmic

Synonyms

CEH; SEH

Species

Homo sapiens

Ensembl Gene

ENSG00000120915

Encoded Proteins

IDBP-14096

epoxide hydrolase 2, cytoplasmic

IDBP-484939

epoxide hydrolase 2, cytoplasmic

IDBP-475548

epoxide hydrolase 2, cytoplasmic

IDBP-479645

epoxide hydrolase 2, cytoplasmic

IDBP-473845

epoxide hydrolase 2, cytoplasmic

IDBP-473359

epoxide hydrolase 2, cytoplasmic

IDBP-485158

epoxide hydrolase 2, cytoplasmic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:27490779-27545564

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000380476	ENSP00000369843
ENST00000521400	ENSP00000430269
ENST00000518328	ENSP00000430779
ENST00000520623
ENST00000517536	ENSP00000428875
ENST00000521780	ENSP00000430302
ENST00000518379	ENSP00000427956
ENST00000520666
ENST00000521684	ENSP00000428191
ENST00000523827
ENST00000521924
ENST00000523326

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004301	epoxide hydrolase activity
GO:0005102	receptor binding
GO:0015643	toxic substance binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0033885	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0042577	lipid phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0016311	dephosphorylation
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042632	cholesterol homeostasis
GO:0044281	small molecule metabolic process
GO:0045909	positive regulation of vasodilation
GO:0046272	stilbene catabolic process
GO:0046839	phospholipid dephosphorylation
GO:0072593	reactive oxygen species metabolic process
GO:0090181	regulation of cholesterol metabolic process

Cellular Component

GO:0005777	peroxisome
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022040

View Gene Order

ENSBTAG00000015241

Not yet available

Pathways

NETPATH

REACTOME

REACT_150417

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00590

Arachidonic acid metabolism pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.212088

RefSeq

NM_001256482 NM_001256483 NM_001256484 NM_001979

HUGO

OMIM

CCDS

CCDS59097 CCDS59098 CCDS6060

HPRD

00582

IMGT

EMBL

GenPept

RNA Seq Atlas