Version 5.4
Homo sapiens Gene: VAMP1
Summary
InnateDB Gene IDBG-14084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAMP1
Gene Name vesicle-associated membrane protein 1 (synaptobrevin 1)
Synonyms SPAX1; SYB1; VAMP-1
Species Homo sapiens
Ensembl Gene ENSG00000139190
Encoded Proteins
IDBP-14088
vesicle-associated membrane protein 1 (synaptobrevin 1)
IDBP-227107
vesicle-associated membrane protein 1 (synaptobrevin 1)
IDBP-237821
vesicle-associated membrane protein 1 (synaptobrevin 1)
IDBP-584647
vesicle-associated membrane protein 1 (synaptobrevin 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6462237-6470987
Strand Reverse strand
Band p13.31
Transcripts
ENST00000361716 ENSP00000355122
ENST00000400911 ENSP00000383702
ENST00000396308 ENSP00000379602
ENST00000544432
ENST00000535180 ENSP00000444181
ENST00000538970
ENST00000535927
ENST00000539047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0016192 vesicle-mediated transport
GO:0035493 SNARE complex assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030337
View Gene Order
ENSBTAG00000014603
Not yet available
Pathways
NETPATH
REACTOME
REACT_11184
Neurotoxicity of clostridium toxins pathway
REACT_228211
Uptake and actions of bacterial toxins pathway
REACT_200617
Toxicity of botulinum toxin type D (BoNT/D) pathway
REACT_200743
Toxicity of botulinum toxin type G (BoNT/G) pathway
REACT_116125
Disease pathway
REACT_200659
Toxicity of botulinum toxin type F (BoNT/F) pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt P23763
TrEMBL
UniProt Splice Variant
Entrez Gene 6843
UniGene Hs.20021
RefSeq NM_016830 NM_001297438 NM_014231 NM_199245 XM_006719014
HUGO HGNC:12642
OMIM 185880
CCDS CCDS44809 CCDS31731 CCDS41740 CCDS73422
HPRD 01716
IMGT
EMBL AC005840 AF060538 BC023286 CH471116 CR542214 CR542231 CR749485 M36196 M36197 M36198 M36199 M36200 Z48924
GenPept AAA60603 AAC28336 AAH23286 CAA88760 CAG47010 CAG47027 CAH18312 EAW88792 EAW88795 EAW88796
RNA Seq Atlas 6843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca