InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RFC1

Summary

InnateDB Gene

IDBG-14028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFC1

Gene Name

replication factor C (activator 1) 1, 145kDa

Synonyms

A1; MHCBFB; PO-GA; RECC1; RFC; RFC140

Species

Homo sapiens

Ensembl Gene

ENSG00000035928

Encoded Proteins

IDBP-14030

replication factor C (activator 1) 1, 145kDa

IDBP-14032

replication factor C (activator 1) 1, 145kDa

IDBP-475597

replication factor C (activator 1) 1, 145kDa

IDBP-473541

replication factor C (activator 1) 1, 145kDa

IDBP-476225

replication factor C (activator 1) 1, 145kDa

IDBP-479449

replication factor C (activator 1) 1, 145kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3\' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:39287456-39366375

Strand

Reverse strand

Band

p14

Transcripts

ENST00000381897	ENSP00000371321
ENST00000349703	ENSP00000261424
ENST00000418436
ENST00000510783
ENST00000502991
ENST00000504974
ENST00000514572	ENSP00000424713
ENST00000505077
ENST00000504554	ENSP00000422129
ENST00000502706
ENST00000509084
ENST00000512881
ENST00000512726
ENST00000504849
ENST00000512275	ENSP00000422475
ENST00000503784	ENSP00000422740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	59 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008047	enzyme activator activity
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006351	transcription, DNA-templated
GO:0007004	telomere maintenance via telomerase
GO:0032201	telomere maintenance via semi-conservative replication
GO:0043085	positive regulation of catalytic activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005663	DNA replication factor C complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030054	cell junction
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome